Cary Grant and Eva Marie Saint in 1959's "North by Northwest."

The 1959 production North by Northwest features the performances of Cary Grant and Eva Marie Saint. Both actors appear together in this specific cinematic work from that year. The sources confirm the presence of Cary Grant and Eva Marie Saint within the movie North by Northwest, highlighting their roles in the 1959 film. This collaboration marks a significant moment for both performers in the classic production, as documented in the provided reports regarding the cast.